Overview

Issues of gynecologic health are commonly seen in post-menopausal women, breast cancer survivors and women who have had a hysterectomy. In the US, as many as 50% of 64 million post-menopausal women suffer from changes to their gynecologic health*, and over 2.8M breast cancer survivors**.

* US Census, 2010   ** National Institutes of Health 2011

The following histological images show the vaginal mucosa before and after the MonaLisa Touch treatment. The marked change to the epithelium post-treatment is clearly illustrated.

MonaLisaTouch_Histology

Histological preparation of a section of the vaginal mucosa stained with haematoxylin and eosin (H&E). (A) Vaginal mucosa in the basal condition with a thinner epithelium. (B) The same patient 2 months after a session with the MonaLisa Touch®. The thicker epithelium and shedding of numerous big cells from the free surface, together with the larger diameter of epithelial cells rich in glycogen, demonstrate the restored metabolic trophism and dynamics of the whole epithelium. [Courtesy of Prof. A. Calligaro. University of Pavia, Italy]

MonaLIsaTouchMOA_static

Two Renewal Mechanisms in One

  • Ablation
  • Thermal effect

Clinical Data

Step 1: Select Clinical Papers for Download

Please select one or more Clinical Paper from the list below. A copy of the selected paper(s) will be emailed to you.

Select Year Title Author Publication Indication
2014 A 12-week treatment with fractional CO2 laser for vulvovaginal atrophy: a pilot study S. Salvatore, R.E. Nappi, N. Zerbinati, A. Calligaro, S. Ferrero, M. Origoni, M. Candiani, and U. Leone Roberti Maggiore Climacteric 2014;17:1-7 Vulvovaginal Atrophy
2014 Microablative fractional CO2 laser improves dyspareunia related to vulvovaginal atrophy: a pilot study Salvatore S,, Leone Roberti Maggiore U., Origoni M., Parma M., Quaranta L., Sileo F., Cola A., Baini I., Ferraro S., Candiani M., Zerbinati N. Journal of Endometriosis and Pelvic Pain Disorders - Vol. 6, No. 3, 2014 Dyspareunia related to vulvovaginal atrophy
2016 An assessment of the safety and efficacy of a fractional CO2 laser system for the treatment of vulvovaginal atrophy Sokol ER, Karram MM Menopause - Vol. 23, No. 10, 2016 Vulvovaginal Atrophy
2016 Fractional microablative CO2 laser for vulvovaginal atrophy in women treated with chemotherapy and/or hormonal therapy for breast cancer; a retrospective study Pagano T., De Rosa P., Vallone R., Schettini F., Arpino G., De Placido S., Nazzaro G., Locci M., De Placido G. Menopause - Vol. 23, No. 10, 2016 Vulvovaginal Atrophy
2016 Is vaginal fractional CO2 laser treatment effective in improving overactive bladder symptoms in post-menopausal patients? Preliminary results Perino A., Cucinella G., Gugliotta G., Saitta S., Polito S., Adile B., Marci R., Calagna G. European Review for Medical and Pharmacological Sciences - Vol. 20, No. 12, 2016 Overactive Bladder
2016 The application of fractional CO2 laser in the treatment of vulvar lichen sclerosus Li J., Miao Y., Wang J. Chinese Journal of Clinical Obstetrics and Gynecology - Vol. 17, No. 4, 2016 Vulvar Lichen Sclerosus
2016 The curative effect and feasibility analysis of fractional CO2 laser in the treatment of vulvovaginaL atrophy in postmenopausal women Miao Y., Li J., Wang J. Chinese Journal of Clinical Obstetrics and Gynecology - Vol. 17, No. 4, 2016 Vulvovaginal Atrophy
2016 Fractional CO2 laser for vulvovaginal atrophy (VVA) dyspareunia relief in breast cancer survivors Pieralli A., Fallani MG., Becorpi A., Bianchi C., Corioni S., Longinotti M., Tredici Z., Guaschino S. Archives of Obstetrics and Gynecology - Vol. 249, No. 4, 2016. Epub 2016 May 12 Vulvovaginal Atrophy in Breast Cancer Survivors
2016 The effect of microablative fractional CO2 laser on vaginal flora of postmenopausal women Athanasiou S., Pitsouni E., Antonopoulou S., Zacharakis D., Salvatore S., Falagas ME., Grigoriadis T. Climacteric - Vol. 19, No. 5, 2016. Epub 2016 Aug 2 Vaginal Flora Effect
2016 Microablative fractional CO2 laser therapy and the genitourinary syndrome of menopause: An observational study Pitsouni E., Grigoriadis T., Tsiveleka A., Zacharakis D., Salvatore S., Athanasiou S. Maturitas - Vol., 94, 2016. Epub 2016 Sep 16 Genitourinary Syndrome of Menopause
2015 The use of pulsed CO2 lasers for the treatment of vulvovaginal atrophy Salvatore S., Athanasiou S., Candiani M. Current Opinion in Obstetrics and Gynecology - Vol. 27, No. 6, 2015 Vulvovaginal Atrophy
2015 Microscopic and ultrastructural modifications of postmenopausal atrophic vaginal mucosa after fractional carbon dioxide laser treatment Zerbinati N., Serati M., Origoni M., Candiani M., Iannitti T., Salvatore S., Marotta F., Calligaro A. Lasers in Medical Science - Vol. 30, No. 1, 2015. Epub 2014 Nov 20 Atrophic Vaginal Mucosa
2015 Sexual function after fractional microablative CO2 laser in women with vulvovaginal atrophy Salvatore S., Nappi RE., Parma M., Chionna R., Lagona F., Zerbinati M., Ferrero S., Origoni M., Candiani M., Leone Roberti Maggiore U. Climacteric - Vol., 18, No. 2, 2015. Epub 2014 Dec 16 Vulvovaginal Atrophy
2015 Vulvo-vaginal atrophy: A new treatment modality using thermoablative fractional CO2 laser Perino A., Calligare A., Fortani F., Tiberio C., Cucinella G., Svelato A., Saitta S., Calagna G. Maturitas - Vol. 80, No. 3, 2015. Epub 2014 Dec 25 Vulvovaginal Atrophy
2016 Fractional CO2 laser treatment of the vestibule for patients with vestibulodynia and genitourinary syndrome of menopause: A pilot study Filippo M., Mickey Karram, Stefano Salvatore, and Raffaele Felice The Journal of Sexual Medicine - Epub 2016 Nov 15 Vestibulodynia and Genitourinary Syndrome of Menopause
2016 Fractional CO2 laser treatment for vaginal atrophy and vulvar lichen sclerosus Michael S. Baggish, MD Journal of Gynecologic Surgery - Vol. 32, No. 6, 2016. Epub Vaginal Atrophy and Vulvar Lichen Sclerosus
2017 Fractional CO2 laser: from skin rejuvenation to vulvo-vaginal reshaping Filippini M., Del Duca L., Negosanti Fl, Bonciani D., Negosanti L., Sannino M., Cannarozzo G., Nisico SP. Photomedicine and Laser Surgery - Vol. 35, No. 3, 2017 Vulvo-vaginal reshaping
2017 Use of novel fractional CO2 laser for the treatment of genitourinary syndrome of menopause: 1-year outcomes Sokol ER, Karram MM Menopause. Epub 2017 Feb 6 Genitourinary Syndrome of Menopause
2017 Safety and long-term efficacy of fractional CO2 laser treatment in women suffering from genitourinary syndrome of menopause Behnia-Willison F., Sarraf S., Miller J., Mohamadi B., Care AS., Lam A., Willison N., Behnia L., Salvatore S. European Journal of Obstetrics Gynecology and Reproductive Biology - Vol. 213, 2017. Epub 2017 Apr 2 Genitourinary Syndrome of Menopause
2017 Fractional CO2 laser therapy: a new challenge for vulvovaginal atrophy in postmenopausal women Siliquini GP., Tuninetti V., Bounous VE., Bert F., Biglia N. Climacteric - Epub 2017 May 15 Vulvovaginal Atrophy
2017 CO2 laser for the genitorurinary syndrome of menopause. How many laser sessions? Athanasiou S., Pitsouni E., Falagas ME., Salvatore S., Grigoriadis T. Maturitas - Epub 2017 Jul 21 Genitourinary Syndrome of Menopause
2017 Lasers for pelvic floor dysfunctions: is there evidence? Lang P., Karram M. Current Opinion in Obstetrics and Gynecology - Epub 2017 Jul 29 Pelvic Floor Dysfunctions
2017 Microablative fractional CO2 laser for the genitourinary syndrome of menopause: power of 30 or 40w? Pitsouni E., Grigoriadis T., Falagas M., Tsiveleka A., Salvatore S., Athanasiou S. Lasers Med Sci - Epub 2017 Aug 2 Genitourinary Syndrome of Menopause
2017 Sexual function in women suffering from genitourinary syndrome of menopause treated with fractionated CO2 laser Salvatore S., Pitsouni E., Del Deo F., Parma M., Athanasiou S., Candiani M. Sexual Medicine Reviews - Epub 2017 Aug 23 Genitourinary Syndrome of Menopause
2017 Long-term reliability of fractioned CO2 laser as a treatment for vulvovaginal atrophy (VVA) symptoms Pieralli A., Bianchi C., Longinotti M., Corioni S., Auzzi N., Becorpi A., Fallani MG., Cariti G., Petraglia F. Archives of Gynecology and Obstetrics - Epub 2017 Sep 2 Vulvovaginal Atrophy
2017 Fractional CO2 laser of the vagina for genitourinary syndrome of menopause: Is the out-of-pocket cost worth the outcome of treatment? Lang P., Dell JR., Rosen L., Weiss P., Karram M. Lasers Surg Med. Epub 2017 Sep 7 Genitourinary Syndrome of Menopause
2015 Histological study on the effects of microablative fractional CO2 laser on atrophic vaginal tissue: an ex vivo study Stefano Salvatore, Umberto Leaone Roberti Maggiore, Stavros Athanasiou, Massimo Origoni, Massimo Candiani, Alberto Calligaro, Nicola Zerbinati Menopause: Vol. 22, No. 8 Atrophic Vaginal Tissue
2017 Randomized, double-blind, placebo-controlled clinical trial for evaluating the efficacy of fractional CO2 laser compared with topical estriol in the treatment of vaginal atrophy in postmenopausal women Vera Cruz, Marcelo Steiner, Luciano Pompei, Rodolfo Strufaldi, Fernando Fonseca, Lucila Santiago, Tali Wajsfeld, Cesar Fernandes Menopause - Vol. 25, No. 1, 2017 Vaginal Atrophy
2017 Long-term effect of thermoablative fractional CO2 laser treatment as a novel approach to urinary incontinence management in women with genitourinary syndrome of menopause Pablo Isaza, Kinga Jaguszewska, Jose Cardona, Mariusz Lukaszuk Int. Urogenecology - Epub 2017 May 18 Urinary Incontinence
2016 Laser de CO2 fraccionado: un nuevo enfoque de tratamiento para incontinencia urinaria de esfuerzo (IUE) en mujeres posmenopausicas Pablo Isaza, Aura Rosas, Diana Rizo Urologia Colombiana Incontinencia Urinaria
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