Proven Technology, Performance, and Profitability

The Smartlipo MPX platform offers a solid state Nd:YAG laser capable of emitting laser energy in two wavelengths: 1064 nm and 1320 nm. These wavelengths can be used independently or blended, using MultiPlex™ (MPX) technology.

Smartlipo MPX—Advanced Laser-Assisted Body Contouring

  • Reduce treatment time with higher power and flexibility using the 1064 nm and 1320 nm wavelengths.
  • Confidence with the SmartSense and ThermaGuide—a patented and unique intelligent delivery system for uniform energy delivery and safety.
  • Blended wavelengths deliver predictable and reproducible results.
  • Drive patients to your practice with prominent Smartlipo brand recognition in print, TV, and social media.

MultiPlex (MPX) – The Power of Two

In MultiPlexTM (MPX) mode, the Smartlipo MPX laser initially fires the 1064 nm wavelength and the energy is distributed into the targeted adipose tissue. The platform laser then fires the 1320 nm wavelength, a wavelength highly absorbed by water, and converts hemoglobin to methemoglobin. This conversion immediately coagulates the surrounding small blood vessels, improving the hemostatic effect. The 1064 nm wavelength also provides tissue retraction through soft tissue coagulation in the treated area.1 The Smartlipo MPX delivers up to 46 watts of power in the blended mode and is supported by the SmartSense and ThermaGuide’s intuitive motion and thermal-sensing technology to deliver precise and controlled body contouring.

Ideal Smartlipo MPX Treatment Applications

Smartlipo MPX is ideal for smaller fat deposits, targeted tissue heating, reduced bleeding and bruising, and tissue retraction.1 1 Intended for the surgical incision, excision, vaporization, ablation, and coagulation of soft tissue.

Accessories (3)


Smartlipo and Cellulaze with SmartSense

Cynosure’s revolutionary Smartlipo™ LaserBodySculpting™ platform is even more precise thanks to SmartSense™—an intelligent handpiece delivery system for Smartlipo™ and Cellulaze… More



Designed to be used with our Smartlipo family of lasers, the ThermaGuide temperature-sensing cannula profiles subdermal temperatures during laser-assisted lipolysis,… More



Cynosure’s ThermaView provides a thermal map of your treatment area, sharing real-time information on skin temperature and eliminating the need… More


SmartLipo MPX Specs


Before & After


Events & Media

Educational Workshops

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Clinical Data

The performance of Smartlipo and Smartlipo MPX is driven by more than nine years of clinical study and evidence-based data.

  1. Anderson RR et al. “Selective Photothermolysis of Lipid Rich Tissues: A Free Electron Laser Study.” Laser in Surgery and Medicine. 38:913–919 (2006).
  2. Apfelberg DB et al. “Progress Report on Multicenter Study of Laser Assisted Liposuction.” Aesth Plast Surg. 18:259–264, 1994.
  3. Badin AZED, Gondek LBE, Garcia MJ, do Valle LC, Flizikowski FBZ, de Noronha L. “Analysis of laser lipolysis effects on human tissue samples obtained from liposuction.” Aesth Plast Surg. 2005;29:281–286.
  4. Badin AZED, Morales LM, Gondek L, Chiaratti MG, Canta L. “Laser Lipolysis: Flaccidity Under Control.” Aesth Plast Surg. 2002; 26:335–339.
  5. Caplin DA, Perlyn, CA. “Rejuvenation of the Aging Neck: Current Principles,Techniques, and Newer Modifications.” Facial Plast Surg Clin N Am 17 (2009) 589–601.
  6. Collawn SS “Skin Tightening with Fractional Lasers, Radiofrequency and Smartlipo.” Annals of Plastic Surgery. Volume 64 Number 5 May 2010.
  7. DiBernardo BE, Reyes J, Chen B. “Evaluation of tissue thermal effects from 1064/1320nm laser assisted lipolysis and its clinical implications.” Journal of Cosmetic and Laser Therapy. 2009; 11:62–69
  8. DiBernardo BE, Reyes J. ”Evaluation of Skin Tightening After Laser Assisted Liposuction.” Aesthetic Surgery Journal. October 2009; 29:5: 400–407.
  9. Goldman A. “Submental Nd:YAG laser-assisted liposuction.” Laser Surg Med. 2006;38:181-184.
  10. Goldman A, Gotkin RH, Sarnoff DS, Prati C, Rossato F. “Cellulite: A New Treatment Approach Combining Subdermal Nd:YAG Laser Lipolysis and Autologus Fat Transplantation.” Aesthetic Surgery Journal. 2008 Vol.28 Number 6: 656–662.
  11. Goldman A, Gotkin RH, “Laser-Assisted Liposuction.” Clinical Plastic Surgery. 36(2009) 241–253.
  12. Goldman A, Schavelzon DE, Blugerman GS. Laserlipolysis: liposuction using Nd-YAG laser. Rev Soc Cir Plást. Jan/abr 2002;17(1):17–26.
  13. Goldman A, Wollina U. Subdermal Nd-YAG laser for axillary hyperhidrosis. Dermatol Surg. 2008;34:1–7.
  14. Goldman A, Wollina U “Lipoma treatment with Subdermal Nd:YAG laser treatment.” International Journal of Dermatology. 2009: 48, 1228–1232.
  15. Ichikawa K, Miyasaka M, Tanaka R, Tanino R, Mizukami K, Wakaki M. Histologic evaluation of the pulsed Nd:YAG laser for laser lypolysis. Laser Surg Med. 2005;36:43-46.
  16. Ichikawa K, Tanino R, Wakaki M. Histologic and photonic evaluation of a pulsed Nd:YAG laser for ablation of subcutaneous adipose tissue. Tokai J Exp Clin Med. 2006;31(4):136–140.
  17. Katz B, McBean J. The new laser liposuction for men. Dermatol Ther. 2007;20:448–451.
  18. Katz B, McBean J. “Laser-assisted lipolysis: A report on complications.” Journal of Cosmetic and Laser Therapy. 2008;10:231–233.
  19. Katz B, McBean J. “A pilot study of the efficacy of a 1064nm and 1320nm sequentially firing Nd:YAG Laser Device for Lipolysis and skin tightening.” Lasers in Surgery and Medicine. 41:779–784 December 2009.
  20. Khoury JG, Saluja R, Keel D, Detwiler S, Goldman MP. Histologic evaluation of interstitial lipolysis comparing a 1064, 1320 and 2100 nm laser in an ex vivo model. Laser Surg Med. 2008;40:402–406.
  21. Kim KH, Geronemus RG. Laser lipolysis using a novel 1,064 nm Nd:YAG laser. American Society for Dermatologic Surgery, Inc. Blackwell Publishing, 2006.
  22. Leibaschoff G et al. “A double-blind, prospective, clinical, surgical, histopathological and ultrasound study comparing the effectiveness and safety of liposuction performed using laser lipolysis (Smartlipo) and Internal Ultrasound (Vaser) method, and assessing the evolution in patients.”
  23. Mordon S, Eymard-Maurin AF, Wassmer B, Ringot J. Histologic evaluation of laser lipolysis: pulsed 1064-nm Nd:YAG laser versus CW 980-nm diode laser. Aesth Surg J. May/June 2007;27(3):263–268.
  24. Prado A, Andrades P, Danilla S, Leniz P, Castillo P, Gaete F. A prospective, randomized, doubleblind, controlled clinical trial comparing laser-assisted lipoplasty with suction-assisted lipoplasty. Plast Reconstr Surg. Sep 15 2006;118(4):1032–1045.
  25. Resko AE, Magro CM, Diktaban T, Sadick NS “Histological Comparison of 1064nm Nd:YAG and 1320nm Nd:YAG Laser Lipolysis Using an ex vivo Model.” Journal of Drugs and Dermatology. Vol.8 Issue 4, April 2009.
  26. Saluja R. “Dual Wavelength Laser lipolysis treatment of Lipomas: A Case Report.” Journal of Drugs in Dermatology. April 2010 Volume 9 Issue 4 pg.387.
  27. Woodhall KE, Saluja R, Khoury J, Goldman M. “A comparison of three separate clinical studies evaluating the safety and efficacy of laser assisted lipolysis using 1064nm, 1320nm and a combined 1064/1320nm multiplex device.” Lasers in Surgery and Medicine. 41:774–778. December 2009.